Brain sync:

In a series of experiments, the researchers implanted the back-mounted devices on mice and then monitored their movements as they explored a rectangular cage. The wireless devices did not reduce the animals’ activity or speed compared with mice that had no device, whereas mice with a cable-powered optogenetic device were sluggish and moved less.

The devices remained functional in the mice for more than nine weeks without damaging brain tissue, the study shows. And similar implants from the team have remained functional for even longer, without causing any noticeable harm, Rogers says. “We’ve had animals that have had these devices basically their whole lives, for 2 years or more, until they die of natural causes.”

The team then tested the devices in mice engineered to express an opsin protein in dopamine neurons in the ventral tegmental area, a brain region involved in reward processing and social behaviors. They placed a mouse with the optogenetic device into a cage with a toy and another mouse of the same sex. Stimulating the dopamine neurons nearly doubled the amount of time mice spent interacting with the other animal but did not change the amount spent near the toy, suggesting the device had successfully targeted the social-reward circuitry.

Brain activity becomes synchronized between people during social interactions, according to previous research. This interbrain synchrony can increase social bonding and may be impaired in people with autism, although research exploring this issue has produced mixed results.

Rogers’ team assessed whether synchronized stimulation of the medial prefrontal cortex, a region of the brain involved in social behavior and cognition, would increase the social bonding of mice. They engineered three mice to express the opsin protein within pyramidal neurons of the medial prefrontal cortex, and then implanted an optogenetic device into each animal.

They stimulated two of the animals with the same frequency and gave the third animal a unique rhythm. The ‘paired’ mice displayed more social behaviors — they approached and sniffed their partner — whereas the third animal exhibited typical, nonsocial behaviors.

The devices can be used to perform even larger, population-based behavioral studies on hundreds of animals at once over long time periods, Rogers says. And they could help provide insight into the mechanisms that underlie atypical social behaviors, Rogers and his colleagues say.

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