Online library details traits linked to genetic conditions

An expanding collection of websites compiles up-to-date information on the characteristics of people with mutations in genes linked to autism and other conditions. The resource, which is freely available online, helps catalog the spectrum of traits tied to rare genetic syndromes.

Over the past decade, researchers have linked many new genes to neurodevelopmental conditions. When scientists identify a novel gene, they generally report their findings in a paper, which typically includes information on about 10 individuals. Clinicians might come across other people with the same genetic condition later on, but they rarely report these additional cases in scientific publications — leaving gaps in what researchers looking to the literature can discover.

“It’s a lot of work to publish single cases nowadays,” says Bert de Vries, associate professor of genetics at Radboud University in Nijmegen, the Netherlands, who led the creation of the resource. “A lot of data actually disappears more or less in a drawer.”

To overcome this problem, de Vries and his colleagues launched the Human Disease Genes websites series in 2016. Since the project’s inception, it has expanded to 225 gene websites, with nearly 200 more on the way, the researchers reported in January in the American Journal of Medical Genetics Part A.

Each website focuses on a specific gene and the syndrome associated with it. Clinicians and researchers can supply additional information about people with mutations in the gene via a short online form, which includes questions about physical, neurological and behavioral traits.

Many of the genes included in the website series are involved in intellectual disability, developmental delay or autism, including ARID1B, CHD8, FOXP2 and ANKRD11.

Expert moderators:

More than 300 expert moderators at clinical genetic centers and research institutions worldwide curate each website. They supply basic information about the genetic conditions and recommendations for managing them.

The moderators also verify the accuracy of any data submitted by other people and anonymize them before adding them to the website. The new data are used to update statistics on the condition’s characteristics, such as the percentage of people with the condition who have autism, seizures or heart problems. A map also shows individuals’ location by country.

Of the 225 gene websites, 95 offer clinical information about people with mutations in the gene and offer data from about 14 case studies, on average.

Several gene websites feature information about more people than can be found in the literature, the researchers report. For example, researchers recently used the ARID1B gene website to collect information on 81 previously unreported people with mutations in that gene, which is linked to autism and a condition called Coffin-Siris syndrome. They used the data to describe the range of characteristics associated with ARID1B mutations.

The website series could help scientists learn more about genetic conditions, the researchers say. It could also provide useful information to clinicians and parents.

The post Online library details traits linked to genetic conditions appeared first on Spectrum | Autism Research News.

Order by: 
Per page:
  • There are no comments yet
Related Feed Entries
Autistic children are up to four times as likely as their non-autistic peers to have digestive problems, and several small studies show they may also have atypical microbial communities living in their guts. But whether those flora contribute to their autism traits remains unclear. The post The gut’…
11 hours ago · From Spectrum News
Roughly 1 in 5 people with autism will have an interaction with law enforcement before they’re 21. At... The post West Virginia Passes Law Requiring Law Enforcement to Undergo Autism Training appeared first on The Autism Site News. Source: The Autism Site
11 hours ago · From The Autism Site
Eva has already been through three years of preschool waiting for a space to open up at a special school or program, but no one will take her. The post Nonverbal Autistic Girl Has Been Turned Away from 20+ Schools, Now Faces a 4th Year of Preschool appeared first on The Autism Site News. Source: The…
11 hours ago · From The Autism Site
The number of therapists certified to provide applied behavior analysis (ABA), a widely used autism therapy, has skyrocketed in the past two decades, yet more than half of all counties in the United States have none, according to a new study. These counties are home to many autistic children, howev…
Yesterday · From Spectrum News
Ron Sandison interviews child musical prodigy Jacob Velazquez For those who missed Jacob Velazquez on America’s Got Talent here’s a video of his appearance: I had the opportunity to ask Jacob a few questions about his autism and his music. 1. How did PDD-NOS effect you as a child and at…
Yesterday · From The Art of Autism
0 votes
01.04.2021 (01.04.2021)
0 Subscribers